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Studies on the Material Properties of Platinum Complex Binding to Human Telomeric G-Quadruplex DNA

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Abstract:

A new material of cation platinum (II) complex has been synthesized and characterized. The new material binding properties with human telomeric G-quadruplex DNA (G4-Htel DNA) and ct-DNA were examined by UV-Vis and CD spectroscopic methods. The results showed that complex exhibited higher binding affinity and binding intensity to G4-Htel DNA (up to Kb = 1.54×106 M-1) and with selectivity (up to 11-fold) over duplex DNA. The CD results suggests the antiparallel structure of G-quadruplex can remain stable in the presence of platinum complex and the complex may bind to DNA by intercalation mode.

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Periodical:

Advanced Materials Research (Volume 700)

Pages:

63-66

DOI:

https://doi.org/10.4028/www.scientific.net/AMR.700.63

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Online since:

May 2013

Authors:

Xu Jian Luo, Qi Pin Qin, Yu Lan Li, Yan Cheng Liu

Keywords:

G-Quadruplex DNA, Interaction, Material Property, Platinum Complex

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© 2013 Trans Tech Publications Ltd. All Rights Reserved

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