The Synthesis of Cephalosporin Intermediates THZ

Cheng Xue Wang; Xu Feng Liu; Zhen Ma

doi:10.4028/www.scientific.net/AMR.709.801

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HomeAdvanced Materials ResearchAdvanced Materials Research Vol. 709The Synthesis of Cephalosporin Intermediates THZ

The Synthesis of Cephalosporin Intermediates THZ

Abstract:

Starting from Penicillin G,the THZ was synthesized through three main steps:esterification,oxidation and ring-opening. The effects of various reaction temperature,reaction time and ratio of reactants on the ring-opening reaction were investigated.The yields of its three step reaction are 91%,95.8% and 77.3%,respectively.The products were characterized by FT-IR,HNMR,Elemental analysis and MS. At 90~95°C and 0.04~0.05Mpa, the yield of THZ was 77.3%.