Rg3 Monomer as a Chemotherapy Drugs Sensitizer to Acute Leukemia Cells

Abstract:

Vincristine (VCR) has been an important first-line anti-cancer drugs, since its inception in 1962.And it is the common treatment drugs of acute leukemia. The mechanism of the action of VCR is the induction of apoptosis in leukemic cells. However, VCR neurotoxicity and its adverse reactions such as bone marrow suppression, neutropenia, anemia and limit its clinical use. The effect of chemotherapy has been severly affected. Rg3 monomer is a natural active ingredient extracted from ginseng,and it can induce apoptosis of tumor cells with very low toxicity to normal cells . In recent years , a series of studies were carried out aimed at reducing the adverse reactions of the VCR , enhancing drug sensitivity[1-3].In this study, the combined effects of VCR and Rg3 monomer in K562 cells cultured in vitro were investigated to provide Rg3 monomer of Ginseng is a sensitizer of chemotherapy drugs as VCR to acute leukemia Cells. We conclude that Rg3 monomer can improve the sensitivity of leukemia cells to VCR according to our experimental results.

• Periodical: Advanced Materials Research (Volume 709)
• Pages: 840-843
• DOI: https://doi.org/10.4028/www.scientific.net/AMR.709.840
• Online since: June 2013
• Authors: Yi Ju Hou, Feng Hao, Xiao Dong Liu, Zhong Hai Yuan, Yan Li
• Keywords: Chemotherapy Sensitizer, K562 Cell, Rg3

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