Expression of CD4⁺CD25⁺T Regulatory Cells and Foxp3 in Peripheral Blood of Patients with Rheumatoid Arthritis Patient

Abstract:

To investigate the expression of CD4+CD25+T cells and the Foxp3 in peripheral blood of rheumatoid arthritis（RA），and to analyze the relationship between their activities and patho- genesis.The number of CD4+CD25+T lymphocytes in the peripheral blood and Foxp3 mRNA expression on peripheral blood monocytes of 48 RA patients and 35 normal controls were analyzed by three-color FACs analysis and reverse transcription-polymerase chain reaction（RT- PCR）．The expression of CD4+CD25+T cells RA patients in active group was significantly lower than that in remission group and healthy controls（P0.05）； The relationship between peripheral blood CD4+CD25+Tregcells as well as the Foxp3 mRNA and active renal score was negatively correlated. The expression of CD4+CD25+Tregcells and the Foxp3 mRNA of peripheral blood in RA patients is abnormal and it is correlated with pathogenesis and activity of RA.

• Periodical: Advanced Materials Research (Volume 709)
• Pages: 844-847
• DOI: https://doi.org/10.4028/www.scientific.net/AMR.709.844
• Online since: June 2013
• Authors: Ke Xin Sun, Yan Li, Su Hong Guo, Yi Ju Hou
• Keywords: CD4⁺CD25⁺Tregcell, Foxp3, PBMC, RA

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