The multi-size Al2O3 particles dispersion strengthened copper base composite (i.e. Al2O3/Cu-0.6%Al2O3 composite) was prepared by the vacuum hot-press sintering-internal oxidizing method. The hot deformation behavior of Al2O3/Cu-0.6%Al2O3 composite was investigated by the isothermal compression tests at the temperature range from 600°C to 950°C and strain rates of 0.001 s-1 and 1s-1 respectively with a Gleeble-1500D thermal simulator system. The results show that the flow stress-strain curves of Al2O3/Cu-0.6%Al2O3 composites indicate the softening mechanism of recrystallization. The flow stress increases with the deformation strain increasing, then decreases and tends to be steady. The hot deformation activation energy is calculated as 116.46 kJ/mol for the Al2O3/Cu-0.6%Al2O3 composite. The strain-stress constitutive equation is established on the basis of above results.