Synthesis of [C5H5NH][Ph2Sn(μ2-SCH2COO)CI] with Good Biological Activity In Vitro Anti-Tumor

Gui Yun Zhong

doi:10.4028/www.scientific.net/AMR.726-731.222

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HomeAdvanced Materials ResearchAdvanced Materials Research Vols. 726-731Synthesis of [C5H5NH][Ph2Sn(μ2-SCH2COO)CI] with...

Synthesis of [C₅H₅NH][Ph₂Sn(μ²-SCH₂COO)CI] with Good Biological Activity In Vitro Anti-Tumor

Abstract:

Five-coordinated anionic tin (IV) complexes [C₅H₅NH][Ph₂Sn (μ²-SCH₂COO)C was synthesized by the reaction of mercaptoacetic acid with diphenyltin dichloride in the present of pyridine. The structure was characterized by elemental analysis, IR, ¹H NMR. The crystal structure of [C₅H₅N[Ph₂Sn (μ²-SCH₂COO)C was determined by X-ray crystallography. The structure consists of an anion part, and a pyridinium cation part as a counterion. The tin atom has a distorted cis-tbp geometry with two carbon and one sulfur atoms occupying the equatorial positions and the o atom and Cl atom occupying the axial positions. We tested the activity of the product in vitro antitumor for A-549, HCT-8 and Bel-7402, results showed that the compound has a strong anti-tumor activity for A-549, HCT-8, IC₅₀ values were 0.91 and 0.34 μg ml^-1, respectively.

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Periodical:

Advanced Materials Research (Volumes 726-731)

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222-224

DOI:

https://doi.org/10.4028/www.scientific.net/AMR.726-731.222

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Online since:

August 2013

Authors:

Gui Yun Zhong*

Keywords:

Anti-Tumor Activity, Biological Activity, Onic Organotin

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