Synthesis and In Vitro Anti-Ulcer Effect of Triazolo-Methyl Tetrahydrobenzofuran Oxime Ether Derivatives

Abstract:

The triazolo-methyl tetrahydrobenzofuran oxime ether isomers were prepared through Cu (II)-catalyzed Huisgen 1,3-dipolar cycloaddition reaction in a high-yielding three-step reaction sequence under mild conditions. All of the intermediates and target compounds were characterized by NMR, IR, ESI-MS and elemental analysis. The in vitro anti-ulcer activity evaluation indicated the (Z)-oxime isomer of triazolo-methyl tetrahydrobenzofuran oxime ether exhibited most potent H⁺/K⁺-ATPase inhibitory effect with the IC₅₀˰̵̱̼͆ͅ˰̶̿˰̅˾́̅˰μ̝˾ These compounds could be potentially used as anti-ulcer agents for the treatment of acid related diseases.

• Periodical: Advanced Materials Research (Volume 746)
• Pages: 35-39
• DOI: https://doi.org/10.4028/www.scientific.net/AMR.746.35
• Online since: August 2013
• Authors: Hu Biao Fang, Lei Jin, Cheng Qiao Cao, Hua Jun Luo, Nian Yu Huang
• Keywords: Anti-Ulcer Agent, H⁺/K⁺-ATPase Inhibitory Activity, Oxime Ether, Synthesis, Triazole

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