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HomeAdvanced Materials ResearchAdvanced Materials Research Vol. 746Synthesis and Structure Elucidation of Novel Oxime...

Synthesis and Structure Elucidation of Novel Oxime Ether Type H/K+-ATPase Inhibitors

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Abstract:

Six 6,6-dimethyl-2-phenyl-6,7-dihydrobenzofuran-4(5H)-one oxime derivatives were synthesized, characterized and evaluated as potential anti-ulcer agents. Most of the target compounds exhibited better H⁺/K⁺-ATPase inhibitory activity than commercial revaprazan, and both of the two O-propyl oxime ethers displayed the most potent activities with IC₅₀˰̵̱̼͆̓ͅ˰̵̼̓̓˰̸̱̈́̾˰́̀˰μ̝˾ These compounds could be potentially used for the treatment of ulcer disease.

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Chemical, Material and Metallurgical Engineering

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Periodical:

Advanced Materials Research (Volume 746)

Pages:

40-44

DOI:

https://doi.org/10.4028/www.scientific.net/AMR.746.40

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Online since:

August 2013

Authors:

Lei Jin, Hu Biao Fang, Nian Yu Huang, Jun Zhi Wang, Kun Zou

Keywords:

H⁺/K⁺-ATPase Inhibitor, Oxime Ether, Structure Elucidation, Synthesis, Tetrahydrobenzofuran

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© 2013 Trans Tech Publications Ltd. All Rights Reserved

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