Preparation of Solid Self-Emulsifying Drug Delivery System of Manidipine Hydrochloride

Tassanee Nernplod; Yotsanan Weerapol; Pornsak Sriamornsak

doi:10.4028/www.scientific.net/AMR.747.143

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HomeAdvanced Materials ResearchAdvanced Materials Research Vol. 747Preparation of Solid Self-Emulsifying Drug...

Preparation of Solid Self-Emulsifying Drug Delivery System of Manidipine Hydrochloride

Abstract:

The ability of self-emulsifying drug delivery system (SEDDS), which is a mixture of oils, surfactants and co-surfactants, to improve dissolution rate of a poorly water-soluble drug, manidipine hydrochloride (MDP), was evaluated in this study. Liquid form of SEDDS containing caprylic/capric glyceride, polyoxyl 35 castor oil, and diethylene glycol monoethyl ether at a weight ratio of 1:1:8 was converted to solid SEDDS by adsorption on to different solid carriers, i.e., Aerosil^® 200 and Sylysia^® 320. The results demonstrated that the solid carrier of at least 50% (w/w) was required to adsorb liquid SEDDS containing MDP. The results from powder X-ray diffraction, differential scanning colorimetry and scanning electron microscopy showed that MDP in solid SEDDS formulations was in amorphous form while a crystalline form was observed only in MDP raw material and its physical mixture. The in vitro dissolution of MDP from solid SEDDS using Sylysia^® 320 was higher than that using Aerosil^® 200 as a solid carrier. In summary, the solid SEDDS could be used as a carrier to improve the dissolution of MDP, a poorly water-soluble drug.

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Advanced Materials Research (Volume 747)

Pages:

143-146

DOI:

https://doi.org/10.4028/www.scientific.net/AMR.747.143

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Online since:

August 2013

Authors:

Tassanee Nernplod, Yotsanan Weerapol, Pornsak Sriamornsak

Keywords:

Aerosil^®, Manidipine Hydrochloride, Self-Emulsifying Drug Delivery System, Sylysia^®

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