Dissolution Improvement of Itraconazole by a Nanoparticulate System Containing Lecithin-Pectin Complexes

Abstract:

Nanoparticulate system composing of polymeric or lipid materials have been proposed as drug carriers for improving efficacy of encapsulated drugs. Different materials, e.g. phospholipids and polysaccharides, have been proposed for the production of these systems due to their biocompatibility, biodegradability, low cost and safety. In this study, we report a novel particulate system containing lecithin-pectin complexes loaded with a lipophilic drug, itraconazole. The effect of pectin concentration on particle formation and drug dissolution was also investigated. The lecithin-pectin complexes were prepared by thin film method using soya lecithin and then hydrated with different concentration of pectin solution. The surface charge (zeta potential) and particle size of complex particles were characterized. The drug dissolution was determined by using USP dissolution apparatus. The results demonstrated that the particle size of complex particles were in nanometer range. When concentration of pectin increased, the size increased slightly while the surface charge of complex particles was less negative. The drug dissolution from complex particles containing lecithin and pectin was higher than those containing only pectin.

• Periodical: Advanced Materials Research (Volume 747)
• Pages: 162-165
• DOI: https://doi.org/10.4028/www.scientific.net/AMR.747.162
• Online since: August 2013
• Authors: Pornsak Sriamornsak, Sontaya Limmatvapirat, Kamonrak Cheewatanakornkool
• Keywords: Lecithin-Pectin Complexes, Lipophilic Drug, Nanoparticulate System

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