Design, Synthesis and Biological Evaluation of Sunitinib Analogues to Improve Aqueous Solubility

Ke Tao Chen; Zheng Fang; Zhao Yang; Kai Guo

doi:10.4028/www.scientific.net/AMR.749.350

Paper Titles

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Facile and Efficient Anti-Fouling Surface Construction on Poly(dimethylsiloxane) via Mussel-Inspired Chemistry
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Design, Synthesis and Biological Evaluation of Sunitinib Analogues to Improve Aqueous Solubility
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HomeAdvanced Materials ResearchAdvanced Materials Research Vol. 749Design, Synthesis and Biological Evaluation of...

Design, Synthesis and Biological Evaluation of Sunitinib Analogues to Improve Aqueous Solubility

Abstract:

In order to improve aqueous solubility of Sunitinib, based on the structure-activity relationship, four analogues were designed and synthesized. The obtained structures were identified by ¹H NMR, MS and elemental analysis. In vitro evaluation of antitumor bioactivity was performed by MTT method. All of synthesized compounds showed antitumor activities, especially, compounds A1, which were better than or equal to the antitumor activity of positive control.

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Advanced Materials Research (Volume 749)

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350-353

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https://doi.org/10.4028/www.scientific.net/AMR.749.350

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Online since:

August 2013

Authors:

Ke Tao Chen, Zheng Fang, Zhao Yang, Kai Guo

Keywords:

Activity, Analogues, Antitumor, Synthesis

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