Synthesis and Characterization of Novel Degradable Responsive Polyurethane Microsphere

Lian Hai Shan; Yuan Yuan Cui; Shuai Huang; Zhi Bin Zhang

doi:10.4028/www.scientific.net/AMR.750-752.1271

Paper Titles

Elution Efficiency of Herbicides Polluted Soil Samples
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Effect Parameters of Ozonation of Dicamba in Aqueous Solution
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Characteristics of Cr (VI) Adsorption in Aqueous Solution by Wheat Straw
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Effect of Different Parameters on Particle Diameters of Magnesium Salt Flame Retardants
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Synthesis and Characterization of Novel Degradable Responsive Polyurethane Microsphere
p.1271

Preparation and Photocatalytic Activity of Fe-Ce-N Tri-Doped TiO₂ Catalysts
p.1276

Kinetics Study on Catalytic Hydrolysis of CCl₂F₂ over Solid Acid MoO₃/ZrO₂
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Comparation of Cu-Co-Mn Mixed Oxides and Hopcalite as Support in Synthesis of Diphenyl Carbonate by Oxidative Carbonylation of Phenol
p.1287

Synthesis of Diphenyl Carbonate by Oxidative Carbonylation of Phenol with Pd-Co/Hopcalite
p.1292

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Synthesis and Characterization of Novel Degradable Responsive Polyurethane Microsphere

Abstract:

The present study describes degradable polyurethane (PU) microspheres fabricated using toluene diisocyanate, polycaprolactone, polyethylene glycol, 2, 2-hydroxymethyl-2-propionic acid and triethylamine for drug delivery. The novel microspheres were synthesized using self-emulsion and condensed phase separation method. Fourier-Transform Infrared Spectrum analysis (FTIR) was performed revealing the chemical structure of polyurethane microspheres with special chains changing. Swelling properties influenced by solvent polarity, PEG content, PEG molecular weight, were evaluated, suggesting that the swelling ratio (SR) of PU microspheres increased with the increase in solvent polarity, PEG content and PEG molecular weight respectively.