Synthesis and Characterization of 7 - (3 - (substituted-phenoxy) propoxy) Quinazoline Derivatives

Abstract:

Four compounds of 7-(3- (substituted-phenoxy) propoxy) quinazoline compounds, including 7-(3-(2,4-dichlorophenoxy) propoxy)-N-(3-chlorophenyl)-6-methoxyquinazolin-4-amine, 7-(3-(2-chlo-rophenoxy) propoxy)-N-(3-chlorophenyl)-6-methoxyquinazolin-4-amine, 7-(3-(4-chlorophenoxy) prop-oxy)-N-(3-chlorophenyl)-6-methoxyquinazolin-4-amine, 7-(3-(naphthalen-3-yloxy) propoxy)-N-(3-chl-orophenyl)-6-methoxyquinazolin-4-amine, were synthesized from N-(5-(3-chloropropoxy)-2-cyano-4-methoxyphen-yl)-N, N-dimethylformamidine by cyclization,etheration, in the yield of 45.9%50.6%56.34% and 80.6% respectively. Their structures were characterized by IR, ¹H NMR, ¹³C NMR, MS and elemental analysis.

• Periodical: Advanced Materials Research (Volumes 781-784)
• Pages: 1003-1006
• DOI: https://doi.org/10.4028/www.scientific.net/AMR.781-784.1003
• Online since: September 2013
• Authors: He Ping Yan, Gui Ping Ouyang*
• Keywords: 4-(3′-Chlorophenylamino)-6-Methoxy Quinazoline, Quinazoline Derivatives, Synthesis

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