Synthesis and Biological Activity of 2-Hydroxy-4-Methoxy Acetophenone Condensed the Aminobenzenearsonic Acid

Jun Sheng Qi; Yu Ling Wang; Yang Cao

doi:10.4028/www.scientific.net/AMR.781-784.1011

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HomeAdvanced Materials ResearchAdvanced Materials Research Vols. 781-784Synthesis and Biological Activity of...

Synthesis and Biological Activity of 2-Hydroxy-4-Methoxy Acetophenone Condensed the Aminobenzenearsonic Acid

Abstract:

2-Hydroxy-4-methoxy acetophenone condensed the Aminobenzenearsonic Acid was synthesized by paeonol and aminobenzenearsonic acid. that is, arsanilic compounds (3b). At the same time, the compound was characterized by IR-NMR-MS, as well as four methyl thiazolyl tetrazolium (MTT) colorimetric assay the arsine compounds (3b) on growth inhibition of human hepatoma cell lines HepG2 cell at different times under different concentration. It is shown that the arsine compounds (3b) can significantly inhibit the growth of human hepatoma cell line HepG2. Its effects were dose-and time-dependent. It is indicated a potential anti-tumor activity.

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Periodical:

Advanced Materials Research (Volumes 781-784)

Pages:

1011-1015

DOI:

https://doi.org/10.4028/www.scientific.net/AMR.781-784.1011

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Online since:

September 2013

Authors:

Jun Sheng Qi, Yu Ling Wang, Yang Cao

Keywords:

Anti-Tumor Activity, Arsine Compounds (3b), MTT Assay, Schiff Base Reaction

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