Electrospray Ionization Mass Spectral Characteristics and Fragmentation Mechanisms of Tanshinones in Radix Salvia miltiorrhiza

Tao Liu; Gui Feng Zhang; Hui Yin; Xiao Bao Jin; Jia Yong Zhu

doi:10.4028/www.scientific.net/AMR.781-784.1027

Paper Titles

Chitosan/Cellulose Microfiltration Membranes for Endotoxin Removal
p.1007

Synthesis and Biological Activity of 2-Hydroxy-4-Methoxy Acetophenone Condensed the Aminobenzenearsonic Acid
p.1011

Comparison of Growth Kinetic of Urinary Crystallites from Patients with Calcium Oxalate Stones with that from Healthy Subjects
p.1016

Antioxidant Activities of Xiao-Yan-Hua-Jie-San and Identification of the Active Components
p.1020

Electrospray Ionization Mass Spectral Characteristics and Fragmentation Mechanisms of Tanshinones in Radix Salvia miltiorrhiza
p.1027

Isolation and Identification of Thermophilic Protease Bacterium 0701 and its Protease Characterization
p.1032

The Relationship between the Micromeritic Properties of Mixture and Raw Materials: Microcrystalline Cellulose and Herba sarcandrae Extract
p.1037

Preparation, Characterization Evaluation of Tanshinone IIA Lipid Microspere and Comparative Study of Pharmacokinetics with Sodium Tanshinone IIA Sulfonate Injection
p.1044

A Study of Characteristic Fragmentation of Different C- and O-Glycosylation Position Flavonoids and their Aglycone by Quadrupole Time-of-Flight Tandem Mass Spectrometry
p.1052

HomeAdvanced Materials ResearchAdvanced Materials Research Vols. 781-784Electrospray Ionization Mass Spectral...

Electrospray Ionization Mass Spectral Characteristics and Fragmentation Mechanisms of Tanshinones in Radix Salvia miltiorrhiza

Abstract:

Cryptotanshinone, tanshinone I, and tanshinone IIA were analyzed by High-performance liquid chromatography /electrospray ionization-mass spectrometry. MSⁿ spectra were obtained and optimized by energy collision induced dissociation (CID) from [M+H]⁺ ions, the effect of collision energy on production of fragmental ions were studied and optimal signals were achieved. With the collision energy of 35%, tanshinones have optimal signals of fragmental ions and maximal amounts of product fragment ions respectively. The fragmentation pathways for the compounds were studied, and this information would be helpful for the quantitative and pharmacokinetic analysis of tanshinones.