Plant Compound Curcumin Increased the Expression of MAP2 in Hippocampal Neurons of APPswe/PS1dE9 Double Transgenic Mice

Dan Li; Chen Wang; Song Tan; Yu Li

doi:10.4028/www.scientific.net/AMR.781-784.717

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HomeAdvanced Materials ResearchAdvanced Materials Research Vols. 781-784Plant Compound Curcumin Increased the Expression...

Plant Compound Curcumin Increased the Expression of MAP2 in Hippocampal Neurons of APPswe/PS1dE9 Double Transgenic Mice

Abstract:

In this study, we aim to investigate the effect of curcumin on the expression of MAP2 in hippocampus in APP/PS1 double transgenic mice. AD model was established with APP/PS1 double transgenic mice, which were fed for 6 months with different concentration of curcumin diet. Immunohistochemistry were applied to evaluate the expressive of MAP2 in hippocampus of transgenic mice. The expression of MAP2 in hippocampus were decreased in APP/PS1 double transgenic mice, but increased in concentration-dependent manner in curcumin treatment group,especially in CA1 and CA3 region. MAP2 may play an important role in the generation or development of AD. MAP2 were injured in APP/PS1 double transgenic mice while curcumin could resume the expression of MAP2. Further research is needed to provide mechanism for this result.

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Periodical:

Advanced Materials Research (Volumes 781-784)

Pages:

717-720

DOI:

https://doi.org/10.4028/www.scientific.net/AMR.781-784.717

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Online since:

September 2013

Authors:

Dan Li, Chen Wang, Song Tan, Yu Li*

Keywords:

Alzheimer's Disease, Curcumin, MAP2, Transgenic Mice

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* - Corresponding Author

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