Continuous Flow Synthesis of Coumarin

Abstract:

Flow chemistry, as a rapidly emerging technology, is exploited to provide a safe and scalable route for the pharmaceutically interesting coumarin. Here, a continuous flow approach for the generation of coumarin is reported, which relies on the two connected coil reactors design. The synthesis of coumarin has been performed successfully in high conversion on small scale and can be scaled up substantially.

• Periodical: Advanced Materials Research (Volumes 781-784)
• Pages: 936-941
• DOI: https://doi.org/10.4028/www.scientific.net/AMR.781-784.936
• Online since: September 2013
• Authors: An Bang Chen*, Xin Li, Yang Zhi Zhou, Ling Ling Huang, Zheng Fang, Hai Feng Gan, Kai Guo
• Keywords: Continuous Flow Approach, Coumarin, Flow Chemistry

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