Study on Hydroxyapatite Fibers with Strontium Reinforced Calcium Phosphate Cement

Abstract:

The solidification time of injectable bone cement should be fit for the clinical application. This research find out the effect of the amount of water-absorbent agent and water-retaining agent. The optimal ratio was be determined. The hydroxyapatite fibers with strontium were added into the CPC. The mechanical property, cytotoxicity test, SEM morphology, XRD and degradation performance in vitro were characterized, respectively. The results show the CPC had the solidification time of 12min when the ratio as below: β-TCP 55.5%, Ca (H₂PO₄)₂H₂O(MCPM)36%, MgHPO₄3H₂O 5%, MgSO₄1%, Sodium pyrophosphate2.5%. The main components of solidify CPC were hydroxyapatite (HA) and dicalcium phosphate dihydrate (DCPD). The materials had a good Anti-collapsing performance and the degradation rate up to 16.72% after 9 weeks. The mechanical property of composite materials which combined with hydroxyapatite fibers with strontium has been improved, and the cell proliferation rate is also higher than common CPC. This study shows a potentially effective method to improve the mechanical property and the biological activity of calcium phosphate cement.

• Periodical: Advanced Materials Research (Volume 788)
• Pages: 119-126
• DOI: https://doi.org/10.4028/www.scientific.net/AMR.788.119
• Online since: September 2013
• Authors: Bin Chu, Jian Xiong, Ming Bo Wang, Xiao Li Li, Zhen Ding She
• Keywords: Calcium Phosphate Cement, Hydroxyapatite Fibers, Strontium

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