ARMOR TPS panel is above the whole ARMOR TPS, and the metal honeycomb sandwich structure is the surface of the ARMOR TPS panel. So the metal honeycomb sandwich structure plays an important role in the ARMOR TPS, while it bears the flight dynamic pressure and stands against the flight dynamic calefaction. So the active environment of metal honeycomb sandwich structure is very formidable. We have to discuss any extreme situation, for reason of making sure aerial vehicle is safe. And high-frequency vibration is one of active environment. In this paper we have analyzed high-frequency vibration response of metal honeycomb sandwich structure. We processed high-frequency vibration experiment by simulating true aerial environment. Sequentially we operated high-frequency vibration experiment of metal honeycomb sandwich structure with cracks, notches and holes. Then finite-element analysis was performed by way of validating the experiment results. Haynes214 is a good high temperature alloy material of both face sheet and core at present, so we choose it in this paper.