Preparation of N, O-Carboxymethyl Chitosan with Different Substitutional Degree and its Application for Hemostasis

Yan Wei Zhao; Lu Liu; Xiang Han; Jing Guan

doi:10.4028/www.scientific.net/AMR.798-799.1061

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HomeAdvanced Materials ResearchAdvanced Materials Research Vols. 798-799Preparation of N, O-Carboxymethyl Chitosan with...

Preparation of N, O-Carboxymethyl Chitosan with Different Substitutional Degree and its Application for Hemostasis

Abstract:

We prepared N, O-carboxymethyl chitosans (CMCSs) with different substitutional degrees (SDs) to evaluate their effects of hemostasis, and provided experimental basis on biomedical materials. Chloroethanoic acid was used to synthesize CMCSs. The structure were characterized by Fourier transform infrared (FT-IR) and wide-angle X-ray diffraction (WXRD). Potentiometric titration and Ubbelohde viscometer were adopted to determine the SD and intrinsic viscosity of CMCSs. Contact angle measurements were investigated to determine surface wettability. Method of dynamic clotting time and coagulation test in vivo were used to evaluate their effects of hemostasis. SDs of CMCSs were from 50% to 110%. As the SD increased, molecular weight decreased. CMCS powder with SD 63% possessed excellent hemostasis both in vitro and in vivo. CMCS powder owned hemostatic capability prior to CS. CMCS powder with SD 63% (neither too high, nor too low) possessed excellent hemostasis both in vitro and in vivo.

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Advanced Materials Research (Volumes 798-799)

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1061-1066

DOI:

https://doi.org/10.4028/www.scientific.net/AMR.798-799.1061

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Online since:

September 2013

Authors:

Yan Wei Zhao, Lu Liu, Xiang Han, Jing Guan

Keywords:

Coagulation Time, N, O-Carboxymethyl Chitosan, Potentiometric Titration, Substitutional Degree

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