Optimization of the NDV-N-2-HACC/CMC Microspheres Preparation

Qian Chen; Hong Kang; Yang Zhang; Hao Wu; Chun Xiao Dai; Chen Guo; Ci Shi; Xin Wang; Zheng Jin; Kai Zhao

doi:10.4028/www.scientific.net/AMR.804.85

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HomeAdvanced Materials ResearchAdvanced Materials Research Vol. 804Optimization of the NDV-N-2-HACC/CMC Microspheres...

Optimization of the NDV-N-2-HACC/CMC Microspheres Preparation

Abstract:

Purpose:in this study, the conditions of the preparation of NDV-N-2-HACC/CMC microspheres are optimized. Methods:Using entrapment efficiency, particle size, Zeta potential as the evaluating indicators, 3 main factors to influence the preparation for microspheres were optimized by orthogonal factorization method. Result:The optimal conditions were 1.0 mg/ml HACC, 1.2 mg/ml CMC, 1:3 (v/v) NDV/HACC, and 1200 r/min and 30 min for stirring. The range of particle size was 192.1-595.2 nm, and average size was 304.3 nm. Zeta potential was +32.50 mV; encapsulation efficiency (EE) was (98.96±2.1) %.Conclusion:the conditions of the preparation of NDV-N-2-HACC/CMC microspheres are optimized.

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Periodical:

Advanced Materials Research (Volume 804)

Pages:

85-88

DOI:

https://doi.org/10.4028/www.scientific.net/AMR.804.85

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Online since:

September 2013

Authors:

Qian Chen, Hong Kang, Yang Zhang, Hao Wu, Chun Xiao Dai, Chen Guo, Ci Shi, Xin Wang, Zheng Jin, Kai Zhao

Keywords:

Micro-Sphere, NDV-N-2-HACC/CMC, Optimization, Preparation

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