Synthesis and Characterization of Crosslinked Galactomannan Nanoparticles for Drug Delivery Application

Rahim Nurnadiah; Dzaraini Kamarun; Abdul Rashid Li; Mohd Radzi Ahmad

doi:10.4028/www.scientific.net/AMR.812.12

Paper Titles

Synthesis and Characterization of Stearoyl Modified Poly (Glycerol Adipate) Containing ATRP Initiator on its Backbone
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Synthesis and Characterization of Crosslinked Galactomannan Nanoparticles for Drug Delivery Application
p.12

The Effects of Acrylamide Loading on the Swelling Capacity of Superabsorbent Polymer in Different Aqueous Medium
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Epoxidation of Palm Oil Catalyzed by Titanium-Grafted Silica Catalyst
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Degradation Behaviour of Thin Polymer Films of Poly(Amide Ester) Hydrogel Using Quartz Crystal Microbalance
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Thermal and Physical Properties; and Surface Morphology of Waterborne Maleinized Epoxidized Soybean Oil Films for Coatings Application
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The Cure Characteristics and Mechanical Behaviour of Bamboo Fibre Filled Natural Rubber Composite
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Effect of Annealing Temperature on the Crystallinity, Morphology and Ferroelectric of Polyvinylidenefluoride-Trifluoroethylene (PVDF-TrFE) Thin Film
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HomeAdvanced Materials ResearchAdvanced Materials Research Vol. 812Synthesis and Characterization of Crosslinked...

Synthesis and Characterization of Crosslinked Galactomannan Nanoparticles for Drug Delivery Application

Abstract:

Galactomannan nanoparticles possess attractive properties such as biodegradable and biocompatible; significant in biomedical applications. Galactomannan (GA) isolated from the mature seed of a local plant, petai belalang known scientifically as Leucaena leucocephala were modified to acrylated galactomannan (AcGA) which acted as a precursor molecule for the preparation of crosslinked galactomannan nanoparticles (CL-GA). AcGA was synthesized using acryloyl chloride (AC) as a chemical modifier through esterification process. Trimethylolpropane triacrylate (TMPTA) was used as the crosslinker for the preparation of CL-GA. Successful conjugation of GA with acrylates was verified by ¹H NMR and FTIR spectroscopies. Thermal properties of pure galactomannan, AcGA and CL-GA were measured using DSC to complement spectroscopic results. TEM images revealed the particle size of AcGA to be in the range of 30-100 nm; and increased to 200-850 nm range after the crosslinking process. Efficiency of CL-GA to trap crystal violet dye as a model drug was followed by UV Vis Spectroscopy. Results showed that CL-GA is capable of trapping crystal violet dye and has the potential to be used as a drug carrier.

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Periodical:

Advanced Materials Research (Volume 812)

Pages:

12-19

DOI:

https://doi.org/10.4028/www.scientific.net/AMR.812.12

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Online since:

September 2013

Authors:

Rahim Nurnadiah, Dzaraini Kamarun, Abdul Rashid Li, Mohd Radzi Ahmad

Keywords:

Acrylated Galactomannan, Crosslinked Galactomannan, Galactomannan, Inverse Microemulsion, Nanoparticle

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