Controlled Release Behaviors of Ketoprofen from Matrix Polymer of Chitosan and poly(ethylene glycol)

Chimsook Thitipha; Thitiphan Chimsook

doi:10.4028/www.scientific.net/AMR.813.399

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HomeAdvanced Materials ResearchAdvanced Materials Research Vol. 813Controlled Release Behaviors of Ketoprofen from...

Controlled Release Behaviors of Ketoprofen from Matrix Polymer of Chitosan and poly(ethylene glycol)

Abstract:

The aim of present work was to prepare floating microsphere of ketoprofen using matrix polymer of chitosan and poly (ethylene glycol) by solvent diffusion method. The floating microsphere of ketoprofen was prepared from matrix polymer of chitosan and poly (ethylene glycol) with various composition ratios and evaluated such as particle size, drug compatibility and drug release of microspheres. The scanning electron microscopy of microspheres confirmed their hollow structures with smooth surface. Formulation CPK 4 to CPK 6 exhibited the best controlled release pattern in ketoprofen. The concentration and size of poly (ethylene-glycol) affected the particle size, percentage yield and drug release of microspheres.

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Periodical:

Advanced Materials Research (Volume 813)

Pages:

399-402

DOI:

https://doi.org/10.4028/www.scientific.net/AMR.813.399

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Online since:

September 2013

Authors:

Chimsook Thitipha, Thitiphan Chimsook

Keywords:

Chitosan, Ketoprofen, Poly(ethylene Glycol)

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References

[1] R. Garg, GD. Gupta, Progress in controlled gastroretentive drug delivery systems, Tropical journal of pharmaceutical research. 7(3) (2008) 1055-1066.

Google Scholar

[2] M. Jaimini, A.C. Rana and Y.S. Tanwar, Formulation and evaluation of Famotidine floating tablets, Current Drug Delivery. 4 (2007) 51-55.

DOI: 10.2174/156720107779314730

Google Scholar

[3] J.H. Lee, T.G. Park, Y.B. Lee, S.C. Chin and H.K. Choi, Effecting of adding nonvolatile oil as a core material for the floating microspheres prepared by emulsion solvent diffusion method, J. Microencapsulation. 18(1) (2001) 65-75.

DOI: 10.1080/026520401750038610

Google Scholar

[4] T.G. Kantor, Ketoprofen: a review of its pharmacologic and clinical properties, Pharmacotherapy. 6 (1986) 93–103.

Google Scholar