Study on Biological Materials with Facile Synthesis and Anti-Breast Cancer Activities of Hydroxylchalcones Derivatives

Kun Jiang; Xin Fei Dong; Xiao Feng Lu; Jun Zhi Wang; Kun Zou; Nian Yu Huang

doi:10.4028/www.scientific.net/AMR.830.459

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HomeAdvanced Materials ResearchAdvanced Materials Research Vol. 830Study on Biological Materials with Facile...

Study on Biological Materials with Facile Synthesis and Anti-Breast Cancer Activities of Hydroxylchalcones Derivatives

Abstract:

Hydroxylchalcone are known to act on various physiological targets. In this study, a series of nine hydroxychalcones were synthesized via the aldol condensation with the aim of obtaining bioactive small molecules. Their structures were characterized by NMR spectra. The anti-breast cancer activity evaluation indicated the monohydroxychalcones exhibited the better anti-proliferative effect than dihydroxylchalcones against MDA-MB-231 cells, and the compound 3b showed the best anti-breast cancer activities at 18 μM. The bioactive compounds might be used to develop as potential anti-breast cancer agents.

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Periodical:

Advanced Materials Research (Volume 830)

Pages:

459-462

DOI:

https://doi.org/10.4028/www.scientific.net/AMR.830.459

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Online since:

October 2013

Authors:

Kun Jiang, Xin Fei Dong, Xiao Feng Lu, Jun Zhi Wang, Kun Zou, Nian Yu Huang*

Keywords:

Anti-Breast Cancer Activity, Hydroxylchalcone, Structure Elucidation, Synthesis

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