Ganoderic Acid Restores the Sensitivity of Multidrug Resistance Cancer Cells to Doxorubicin

Jing Jing Ouyang; Yu Qiang Wang; Wen Tang

doi:10.4028/www.scientific.net/AMR.834-836.573

Paper Titles

Preparation and Characterization of Cellulose Films with Curcumin
p.555

Study the Effect of HAp Content in PLA/HAp Microsphere on the Efficiency of Drug (Clindamycin) Loading Process
p.559

Synthesis and Antiproliferative Activities of Novel 2-Phenylaminopyrimidine (PAP) Derivatives
p.563

The Effect and Mechanism of Apoptosis on Hela Cells Induced by Bufotalin
p.568

Ganoderic Acid Restores the Sensitivity of Multidrug Resistance Cancer Cells to Doxorubicin
p.573

Antioxidant Activities of Flavonoids from Canavalia maritime
p.577

Development of Selective Blue-Laser Lithography for Biomedical Applications: A Pilot Study
p.582

The Structure and Corrosion Process Characterization of Galvannealed and Galvanized Steel Sheets
p.589

Modeling and Experimental Study of the Supporting Force of Water Striders Legs
p.597

HomeAdvanced Materials ResearchAdvanced Materials Research Vols. 834-836Ganoderic Acid Restores the Sensitivity of...

Ganoderic Acid Restores the Sensitivity of Multidrug Resistance Cancer Cells to Doxorubicin

Abstract:

Ganoderic acid R (GA-R) possessed significant cytotoxicity on a multidrug resistance (MDR) tumor cell line (KB-A-1/Dox) and a sensitive tumor cell line (KB-A-1). The results indicated that the inhibition effect of the GA-R was due to the induction of apoptosis. The use of GA-R in vitro resulted in a restoration response of the KB-A-1/Dox cells to the anti-tumor drug doxorubicin by stimulating the drug accumulation within the cells. The index of MDR reversion of GA-R was about 22 folds. The findings show that the ganoderma triterpene may be good candidates for anti-tumor and anti MDR chemotherapy.

You might also be interested in these eBooks

Research in Materials and Manufacturing Technologies

View Preview

Info:

Periodical:

Advanced Materials Research (Volumes 834-836)

Pages:

573-576

DOI:

https://doi.org/10.4028/www.scientific.net/AMR.834-836.573

Citation:

Cite this paper

Online since:

October 2013

Authors:

Jing Jing Ouyang*, Yu Qiang Wang, Wen Tang

Keywords:

Apoptosis, Doxorubicin, Ganoderic Acid, Multidrug Resistance

Export:

RIS, BibTeX

Price:

Permissions CCC:

Request Permissions

Permissions PLS:

Request Permissions

Сopyright:

Citation:

* - Corresponding Author

References

[1] T. Tsuruo, H. Lida, S. Tsukagoshi, J. Sakurai: Cancer Research Vol. 41(1981), p. (1967).

Google Scholar

[2] SPC. Cole, G. Bhardwaj, JH. Gerlach, JE. Mackie, CE. Grant, KC. Almquist, AJ. Stewart, EU. Kurtz, AMV. Duncan, RG. Deeley: Science Vol . 258(1992), p.1650.

DOI: 10.1126/science.1360704

Google Scholar

[3] K. R, H. S Brinkma: Pharmacogenomics Vol . 2(2001), p.51.

Google Scholar

[4] J.D. Park, D.K. Rhee and Y.H. Lee: Phytochemistry Reviews Vol. 2-3(2005), p.159.

Google Scholar

[5] B.S. Min, J. J Gao, N. Nakamura and M. Hmattori: Chem. Pharm. Bull. Vol. 48 (2000), p.1026.

Google Scholar

[6] W.M.W. Cheung, W.S. Hui, P.W.K. Chu, S.W. Chiu, N.Y. Ip: FEBS letters Vol. 486(2000), p.291.

Google Scholar

[7] D.Z. Wei Y.Y. Mei, J.W. Liu: Biotechnology letters Vol. 25(2003), p.291.

Google Scholar