Study the Effect of HAp Content in PLA/HAp Microsphere on the Efficiency of Drug (Clindamycin) Loading Process

Juntima Pradid; Wirunya Keawwattana; Siree Tangbunsuk

doi:10.4028/www.scientific.net/AMR.834-836.559

Paper Titles

Preparation of Guiqi Polysaccharide and Antioxidant Activity In Vitro
p.539

Solvothermal Synthesis, Structure, Fluorescence and Magnetism Properties of a Novel 3D Metal-Organic Framework Based on Tetranuclear Copper Secondary Building Units
p.543

Calcium Methoxide Synthesis from Quick Lime Using as Solid Catalyst in Refined Palm Oil Biodiesel Production
p.550

Preparation and Characterization of Cellulose Films with Curcumin
p.555

Study the Effect of HAp Content in PLA/HAp Microsphere on the Efficiency of Drug (Clindamycin) Loading Process
p.559

Synthesis and Antiproliferative Activities of Novel 2-Phenylaminopyrimidine (PAP) Derivatives
p.563

The Effect and Mechanism of Apoptosis on Hela Cells Induced by Bufotalin
p.568

Ganoderic Acid Restores the Sensitivity of Multidrug Resistance Cancer Cells to Doxorubicin
p.573

Antioxidant Activities of Flavonoids from Canavalia maritime
p.577

HomeAdvanced Materials ResearchAdvanced Materials Research Vols. 834-836Study the Effect of HAp Content in PLA/HAp...

Study the Effect of HAp Content in PLA/HAp Microsphere on the Efficiency of Drug (Clindamycin) Loading Process

Abstract:

An ultrasound field was applied to obtain Polylactic acid (PLA)/Hydroxyapatite (HAp) biocomposite microspheres with the specific core-shell structure to be applied as a carrier of a drug. The hydroxyapatite was obtained from crocodile bone by thermal process. Sample characterization was achieved by powder X-ray diffraction (XRD), Energy-dispersive X-ray spectroscopy (EDX) Scanning electron microscopy (SEM) and High Performance Liquid Chromatography (HPLC). As the result, the PLA/HAp loading clindamycin with different polymer-to-ceramic part wt.% ratio (100:0, 90:10, 80:20, and 70:30) showed the agglomeration of sphere-like particles. In addition, the loading efficiency of clindamycin increased with increasing HAp content up to 20%.

You might also be interested in these eBooks

Research in Materials and Manufacturing Technologies

View Preview

Info:

Periodical:

Advanced Materials Research (Volumes 834-836)

Pages:

559-562

DOI:

https://doi.org/10.4028/www.scientific.net/AMR.834-836.559

Citation:

Cite this paper

Online since:

October 2013

Authors:

Juntima Pradid, Wirunya Keawwattana*, Siree Tangbunsuk

Keywords:

Clindamycin, Drug Loading, Hydroxyapatite (HAP), Poly(lactic acid) (PLA)

Export:

RIS, BibTeX

Price:

Permissions CCC:

Request Permissions

Permissions PLS:

Request Permissions

Сopyright:

Citation:

* - Corresponding Author

References

[1] U. Boonyang, P. Chaopanich, A. Wongchaisuwat, P. Senthongkaew, S. Siripaisarnpipat: Biomimetics, Biomaterials and Tissue Engineering Vol. 5 (2010), p.31.

DOI: 10.4028/www.scientific.net/jbbte.5.31

Google Scholar

[2] G. Wei, P.X. Ma: Biomateriais Vol. 25 (2004), p.4749.

Google Scholar

[3] W.J.E. M Habraken, J.G.C. Wolke, J.A. Jansen: Advanced Drug Delivery Reviews Vol. 59 (2007), p.234.

Google Scholar

[4] H. Hamishehkar, J. Emami, AR. Najafabadi, K. Gilani., M. Minaiyan, H. Mahdavi, A. Nokhodchi: Colloids and Surfaces B: Biointerfaces Vol. 74 (2009), p.340.

DOI: 10.1016/j.colsurfb.2009.08.003

Google Scholar

[5] T. Takei, M. Yoshida, Y. Hatate, K. Shiomori, S. Kiyyama: Polymer Bulletin Vol. 61 (2008), p.391.

Google Scholar

[6] M. Jevti´c, A. Radulovic´, N. Ignjatovic´, M. Mitric´, D. Uskokovic´: ActaBiomaterialia Vol . 5 (2009), p.208.

Google Scholar