An H-Phosphonate Strategy for the Synthesis of Aciclovir 5′-triphosphate

Abstract:

Nucleside 5′-triphosphates (NTPs) play pivotal roles in biology and medicine. However, their synthesis still remains a challenge. We developed a general approach to the synthesis of aciclovir 5′-triphosphate by coupling intermediate pyridinium phosphoramidate with pyrophosphate.

• Periodical: Advanced Materials Research (Volume 848)
• Pages: 215-218
• DOI: https://doi.org/10.4028/www.scientific.net/AMR.848.215
• Online since: November 2013
• Authors: Si Liu, Shan Shan Gong, Qi Sun*
• Keywords: H-Phosphonate, Nucleoside Analogue, Pyrophosphate, Triphosphate

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