Biocompatibility Evaluation on Bio-Soluble Glass for Neural Application

Rui Qi Lim; Kwan Ling Tan; Wei Guo Chen; Min Kyu Je; Ming Yuan Cheng

doi:10.4028/www.scientific.net/AMR.849.177

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HomeAdvanced Materials ResearchAdvanced Materials Research Vol. 849Biocompatibility Evaluation on Bio-Soluble Glass...

Biocompatibility Evaluation on Bio-Soluble Glass for Neural Application

Abstract:

This work evaluated the biocompatibility and the bio-degradability/bio-solubility by comparing different bio-soluble glass materials for neural probe applications. Diboron trioxide and phosphorus oxide based bio-soluble glass materials are used as probe substrate. Two experiments conducted will be discussed in this paper. The first experiment is preliminary bench test to study the dissolution rate of the samples. Second experiment is an in vivo experiment to further investigate the dissolution rate and the biocompatibility of the material. According to the experimental results, higher content (how high) of diboron trioxide glass has a shorter dissolution period (how long) and evoke less inflammatory response compared to a sample with lower content of diboron trioxide and phosphorus oxide based glass. Phosphorus oxide based glass which produces an acidic medium resulting in advance inflammatory response is not suitable as base substrate material for neural probe application.

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Periodical:

Advanced Materials Research (Volume 849)

Pages:

177-182

DOI:

https://doi.org/10.4028/www.scientific.net/AMR.849.177

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Online since:

November 2013

Authors:

Rui Qi Lim*, Kwan Ling Tan, Wei Guo Chen, Min Kyu Je, Ming Yuan Cheng

Keywords:

Biocompatibility, Bio-Soluble Glass, Diboron Trioxide Based Glass, Neural Probe, Phosphorus Oxide Based Glass

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