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HomeAdvanced Materials ResearchAdvanced Materials Research Vol. 859An Efficient Synthesis of an AKT Inhibitor-IV...

An Efficient Synthesis of an AKT Inhibitor-IV Analog Labeled with Biotin

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Abstract:

An AKTI-IV analog with a biotinylated linker extended from the position of the ethyl group in AKTI-IV have been designed and synthesized. Compared to previous alkylation strategy with the iodo biotin linker, the present method alkylated the linker without biotin moiety. The final biotinylation with biotin-OSU afforded the target molecule in much higher overall yield.

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Periodical:

Advanced Materials Research (Volume 859)

Pages:

349-352

DOI:

https://doi.org/10.4028/www.scientific.net/AMR.859.349

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Online since:

December 2013

Authors:

Zhen Biao Xie, Shan Shan Gong, Qi Sun*

Keywords:

AKT, Alkylation, Antiviral, Biotin, Protein Kinase

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© 2014 Trans Tech Publications Ltd. All Rights Reserved

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* - Corresponding Author

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