Partitioning Behavior of Penicillin G in Aqueous Two Phase System Based on Ionic Liquids

Abstract:

An aqueous two-phase system (ATPS) was presented with hydrophilic ionic liquid 1-Butyl-3-methylimid-azolium tetrafluoroborate ([BmiBF₄) and salts for the extraction of penicillin G in this paper. The phase forming abilities of different salts were investigated to choose a suitable salt.The partitioning behavior of penicillin G in the ATPS was investigated.Concentrations of (NH₄)₂SO₄, penicillin G, and [BmiBF₄ were evaluated to determine their effects on the extraction yield of penicillin G. It was found that extraction yield strongly depended on the concentration of [BmiBF₄, penicillin and (NH₄)₂SO₄. A high extraction yield around 93% was achieved with the following parameters: (NH₄)₂SO₄ 20% (wt%), penicillin 40000 ~ 45000 U/mL, [BmiBF₄ 20% (wt%).

• Periodical: Advanced Materials Research (Volumes 864-867)
• Pages: 324-327
• DOI: https://doi.org/10.4028/www.scientific.net/AMR.864-867.324
• Online since: December 2013
• Authors: Bin Jiang, Zhi Biao Feng*, Chun Hong Liu, Ying Cao Xu, Dong Mei Li, Guo Ji
• Keywords: Aqueous Two-Phase System, Extraction, Ionic Liquid (IL), Penicillin G

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