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HomeAdvanced Materials ResearchAdvanced Materials Research Vols. 881-883Fabrication of Paper-Based Microfluidics by...

Fabrication of Paper-Based Microfluidics by Single-Step Wax Printing for Portable Multianalyte Bioassays

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Abstract:

In this paper, we initially report a new type of wax printing method for rapid fabrication of microfluidic devices in paper using a commercially available, cheap, minitype (home-use) CO₂ laser engraving machine. This method combines the two core operations commonly involved in all previous wax printing methods, namely the printing and heating (melting) of wax patterns into one operation of engraving home-made wax slice (put in contact with the surface of paper) by laser. The heat produced by the laser makes the wax being engraved melt and then spread into paper to form complete hydrophobic barriers which are used to define the hydrophilic flow channels or separate test microzones. Under the optimized experimental conditions, a typical device on a 3 cm × 3 cm piece of paper could be fabricated separately within ~320 sec and is ready for use once the engraving process is completed. The fabrication resolution and multiplexed analytical capability of the wax-patterned paper were additionally characterized.

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Periodical:

Advanced Materials Research (Volumes 881-883)

Pages:

503-508

DOI:

https://doi.org/10.4028/www.scientific.net/AMR.881-883.503

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Online since:

January 2014

Authors:

Cai Bin Zhou, Yun Zhang*, Shang Wang Le, Jin Fang Nie, Ting Zhang, Fang Liu, Jian Ping Li

Keywords:

Colorimetric Assay, Laser Engraving, Multianalyte Bioassay, Paper-Based Microfluidics, Point-of-Care Diagnostic Device

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© 2014 Trans Tech Publications Ltd. All Rights Reserved

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[1] X. Li, D.R. Ballerini and W. Shen: Biomicrofluidics Vol. 6 (2012), pp.011301-1.

[2] A.W. Martinez, S.T. Phillips, G.M. Whitesides and E. Carrilho: Anal. Chem. Vol. 82 (2010), p.3.

[3] A.W. Martinez, S.T. Phillips, M.J. Butte and G.M. Whitesides: Angew. Chem. Int. Ed. Vol. 46 (2007), p.1318.

[4] A.W. Martinez, S.T. Phillips, B.J. Wiley, M. Gupta and G.M. Whitesides: Lab Chip Vol. 8 (2008), p.2146.

[5] E. Carrilho, A.W. Martinez and G.M. Whitesides: Anal. Chem. Vol. 81 (2009), p.7091.

[6] G.G. Lewis, M.J. DiTucci, M.S. Baker and S.T. Phillips: Lab Chip Vol. 12 (2012), p.2630.

[7] Y. Lu, W.W. Shi, L. Jiang, J.H. Qin and B.C. Lin: Electrophoresis Vol. 30 (2009), p.1497.

[8] Y. Lu, W.W. Shi, J.H. Qin and B.C. Lin: Anal. Chem. Vol. 82 (2010), p.329.

[9] J.L. Delaney, C.F. Hogan, J.F. Tian and W. Shen: Anal. Chem. Vol. 83 (2011), p.1300.

[10] C.G. Shi, X. Shan, Z.Q. Pan, J.J. Xu, C. Lu, N. Bao and H.Y. Gu: Anal. Chem. Vol. 84 (2012), p.3033.

[11] A. Määttänen, D. Forsa, S.X. Wang, D. Valtakaria and P. Ihalainena: Sens. Actuators B: Chem. Vol. 160 (2011), p.1404.

[12] J. Olkkonen, K. Lehtinen and T. Erho: Anal. Chem. Vol. 82 (2010), p.10246.

[13] C.M. Cheng, A.D. Mazzeo, J.L. Gong, A.W. Martinez, S.T. Phillips, N. Jain and G.M. Whitesides: Lab Chip Vol. 10 (2010), p.3201.

[14] X. Li, J. Tian, T. Nguyen and W. Shen: Anal. Chem. Vol. 80 (2008), p.9131.

[15] G. Chitnis, Z.W. Ding, C.L. Chang, C.A. Savranacde and B. Ziaie: Lab Chip Vol. 11 (2011), p.1161.

[16] E.M. Fenton, M.R. Mascareñas, G.P. Lopez and S.S. Sibbett: ACS Appl. Mater. Interfaces Vol. 1 (2009), p.124.

[17] J.F. Nie, Y.Z. Liang, Y. Zhang, S.W. Le, D.N. Li and S.B. Zhang: Analyst Vol. 138 (2012), p.671.

[18] D.A. Bruzewicz, M. Reches and G.M. Whitesides: Anal. Chem. Vol. 80 (2008), p.3387.

[19] J.F. Nie, Y. Zhang, L.W. Lin, C.B. Zhou, S.H. Li, L.M. Zhang and J.P. Li: Anal. Chem. Vol. 84 (2012), p.6331.

[20] W. Dungchai, O. Chailapakul and C.S. Henry: Analyst Vol. 136 (2011), p.77.

[21] K.M. Schilling, A.L. Lepore, J.A. Kurian and A.W. Martinez: Anal. Chem. Vol. 84 (2012), p.1579.

[22] S.M.Z. Hossain and J.D. Brennan: Anal. Chem. Vol. 83 (2011), p.8772.

[23] M.M. Mentele, J. Cunningham, K. Koehler, J. Volckens and C.S. Henry: Anal. Chem. Vol. 84 (2012), p.4474.

[24] S.J. Vella, P. Beattie, R. Cademartiri, A. Laromaine, A.W. Martinez, S.T. Phillips, K.A. Mirica and G.M. Whitesides: Anal. Chem. Vol. 84 (2012), p.2883.

DOI: 10.1021/ac203434x

[25] J.C. Jokerst, J.A. Adkins, B. Bisha, M.M. Mentele, L.D. Goodridge and C.S. Henry: Anal. Chem. Vol. 84 (2012), p.2900.

DOI: 10.1021/ac203466y

[26] Jr.J.D. Peele, R.H. Gadsden and R. Crews: Clin. Chem. Vol. 23 (1977), p.2242.

[27] M.J. Pugia, J.A. Lott, J.A. Profitt and T.K. Cast: J. Clin. Lab. Anal. Vol. 13 (1999), p.180.