Stereo-Controlled Total Synthesis of Ieodomycins A and B

Cheng Lin Zhu; Jian Ting Zhang; Shi Peng Chen; Jun Min Feng; Gao Peng Wang; Yu Ping Li; Shuang Ping Huang; Xiao Ji Wang

doi:10.4028/www.scientific.net/AMR.881-883.57

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HomeAdvanced Materials ResearchAdvanced Materials Research Vols. 881-883Stereo-Controlled Total Synthesis of Ieodomycins A...

Stereo-Controlled Total Synthesis of Ieodomycins A and B

Abstract:

A highly convergent formal synthesis of Ieodomycins A and B was achieved in 7 steps. The key features involved in the synthetic sequence of Ieodomycins A and B are the Sharpless asymmetric epoxidation and the Mukaiyama aldol reaction^[. The synthesis of C-3 epimer of Ieodomycins A and B was also accomplished in good yields, but now just Heptyl diene aldehyde was getted thought 4 steps. Use Geraniol as meterials to make the corresponding aldehyde (1) via Swern oxidation. Though epoxidation, Wittig reaction and HIO₄oxidation to get the intermediate . Useing it though few steps, the target molecule can be getted.

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Periodical:

Advanced Materials Research (Volumes 881-883)

Pages:

57-60

DOI:

https://doi.org/10.4028/www.scientific.net/AMR.881-883.57

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Online since:

January 2014

Authors:

Cheng Lin Zhu, Jian Ting Zhang, Shi Peng Chen, Jun Min Feng, Gao Peng Wang, Yu Ping Li, Shuang Ping Huang, Xiao Ji Wang

Keywords:

Epoxidation, Ieodomycin, Synthesis

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References

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