Deposition of Functional Polymer Thin Films Using Atmospheric Pressure Plasma for Biomedical Applications – Endothelialization of Vascular Prostheses

Abstract:

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Functionalized plasma polymer thin films were obtained in a dielectric barrier discharge at atmospheric pressure in an atmosphere of N2 and C2H4. The coatings were hydrophilic, adherent, chemically stable and presented a surface concentration of NH2 suitable for further biomolecule conjugation. Covalent grafting of a linking arm (glutaric anhydride) and subsequent conjugation of fibronectin, a protein of the extracellular matrix, were successful. Finally, endothelial cell adhesion experiments were performed directly on the functionalized thin films as well as on the conjugated coatings. Effects on cell adhesion were observed as a function of the plasma thin film deposition parameters.

Info:

Periodical:

Advanced Materials Research (Volumes 89-91)

Edited by:

T. Chandra, N. Wanderka, W. Reimers , M. Ionescu

Pages:

479-484

DOI:

10.4028/www.scientific.net/AMR.89-91.479

Citation:

C. Sarra-Bournet et al., "Deposition of Functional Polymer Thin Films Using Atmospheric Pressure Plasma for Biomedical Applications – Endothelialization of Vascular Prostheses", Advanced Materials Research, Vols. 89-91, pp. 479-484, 2010

Online since:

January 2010

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$35.00

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