Deposition of Functional Polymer Thin Films Using Atmospheric Pressure Plasma for Biomedical Applications – Endothelialization of Vascular Prostheses

Christian Sarra-Bournet; Karine Vallières; Nicolas Gherardi; Stephane Turgeon; Francoise Massines; Gaetan Laroche

doi:10.4028/www.scientific.net/AMR.89-91.479

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Deposition of Functional Polymer Thin Films Using Atmospheric Pressure Plasma for Biomedical Applications – Endothelialization of Vascular Prostheses
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HomeAdvanced Materials ResearchAdvanced Materials Research Vols. 89-91Deposition of Functional Polymer Thin Films Using...

Deposition of Functional Polymer Thin Films Using Atmospheric Pressure Plasma for Biomedical Applications – Endothelialization of Vascular Prostheses

Abstract:

Functionalized plasma polymer thin films were obtained in a dielectric barrier discharge at atmospheric pressure in an atmosphere of N2 and C2H4. The coatings were hydrophilic, adherent, chemically stable and presented a surface concentration of NH2 suitable for further biomolecule conjugation. Covalent grafting of a linking arm (glutaric anhydride) and subsequent conjugation of fibronectin, a protein of the extracellular matrix, were successful. Finally, endothelial cell adhesion experiments were performed directly on the functionalized thin films as well as on the conjugated coatings. Effects on cell adhesion were observed as a function of the plasma thin film deposition parameters.

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Periodical:

Advanced Materials Research (Volumes 89-91)

Pages:

479-484

DOI:

https://doi.org/10.4028/www.scientific.net/AMR.89-91.479

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Online since:

January 2010

Authors:

Christian Sarra-Bournet, Karine Vallières, Nicolas Gherardi, Stephane Turgeon, Francoise Massines, Gaetan Laroche

Keywords:

Atmospheric Pressure, Biomaterial, Biomedical, Plasma Deposition, Thin Film

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