Nanocomposite Multilayer Fibrous Membrane for Sustained Drug Release

Abstract:

Building on the success of the many earlier studies on electrospun nanofibers technique which provide a non woven web to the order of nanometers introducing superior properties such as large surface area, superior mechanical properties and ease of implementation in many fields of applications, elctrospun nanofibers became an important issue for many researchers in various fields. Using elctrospun fibers as a drug carrier, is showing a huge promising potential for the future of biomedical application. Our work in this research is focusing on engineering a system to control the drug release profile rate especially for wound dressing. Nanocomposite multilayer fibrous membranes, using electrospinning method, have been developed for drug release in form of sandwich structure of three layers. Inner layer which is kept Polycaprolactane (PCL) loaded with drug. The two outer layers have been changed with different blend ratios between Chitosan (Cs) and PCL as follow [0%:100% Cs:PCL, 30%:70% Cs:PCL, 50%:50% Cs:PCL, 70%:30% Cs:PCL]. The results showed that the release rate has been affected dramatically by the outer layer composition. SEM images showed changing in the morphology due to the different in the composition of outer layer.

• Periodical: Advanced Materials Research (Volume 894)
• Pages: 364-368
• DOI: https://doi.org/10.4028/www.scientific.net/AMR.894.364
• Online since: February 2014
• Authors: Ahmed Hassanin, Ahmed Abd El-Moneim, Mohamed Ghaniem, Hassan Nageh
• Keywords: Chitosan, Ciprofloxacine HCL, Drug Release, Nanofibre, Polycaprolactone

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