Elastin-Like Polypeptides as Thermosensitive Polymer System

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Abstract:

Thermo-responsive elastin-like polypeptides (ELPs) were successfully obtained by inverse transition cycling (ITC) and recursive directional ligation (RDL). Six ELPs displayed thermal properties, depending on their sequence and chain length. It was found that the ELP[KV8F-4 and ELP[KV8F-8 were effective as thermosensitive materials at the body temperature with phase transition temperature from 35 to 45oC.

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296-299

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February 2014

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© 2014 Trans Tech Publications Ltd. All Rights Reserved

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[1] A.O. Elzoghby, W.M. Samy, N.A. Elgindy, J Control Release 161 (2012) 38-49.

Google Scholar

[2] D.E. Meyer, A. Chilkoti, Biomacromolecules 3 (2002) 357-367.

Google Scholar

[3] D.W. Urry, The Journal of Physical Chemistry B 101 (1997) 11007-11028.

Google Scholar

[4] D.W. Lim, K. Trabbic-Carlson, J.A. MacKay, A. Chilkoti, Biomacromolecules 8 (2007) 1417-1424.

Google Scholar

[5] L.A. Strzegowski, M.B. Martinez, D.C. Gowda, D.W. Urry, D.A. Tirrell, Journal of the American Chemical Society 116 (1994) 813-814.

DOI: 10.1021/ja00081a070

Google Scholar

[6] Y. Cho, Y. Zhang, T. Christensen, L.B. Sagle, A. Chilkoti, P.S. Cremer, The Journal of Physical Chemistry B 112 (2008) 13765-13771.

DOI: 10.1021/jp8062977

Google Scholar

[7] J.C. Rodríguez-Cabello, L. Martín, A. Girotti, C. García-Arévalo, F.J. Arias, M. Alonso, Nanomedicine 6 (2011) 111-122.

DOI: 10.2217/nnm.10.141

Google Scholar

[8] R.L. DiMarco, S.C. Heilshorn, Advanced Materials 24 (2012) 3923-3940.

Google Scholar

[9] F.M. Ausubel, Current protocols in molecular biology, J. Wiley, (1987).

Google Scholar

[10] J.R. McDaniel, D.J. Callahan, A. Chilkoti, Advanced drug delivery reviews 62 (2010) 1456-1467.

DOI: 10.1016/j.addr.2010.05.004

Google Scholar

[11] J.L. Frandsen, H. Ghandehari, Chemical Society Reviews 41 (2012) 2696-2706.

Google Scholar

[12] G.L. Bidwell, Therapeutic delivery 3 (2012) 609-621.

Google Scholar