Local Delivery System Using Thermosensitive Hydrogel and Drug Loading Microspheres for Cartilage Repairing

Lei Wang; Gang Wu

doi:10.4028/www.scientific.net/AMR.898.300

Paper Titles

Oral Rapid-Dissolving Polymeric Nanoparticles of Acetaminophen Fabricated Using Electrospraying
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The Conjecture of Obtain C₄H₅O⁺ Fragments by Cyclicketone Ion Excited State
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Type IV Dental Stone Incorporated with Antimicrobial Agents and its Physical Properties
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Elastin-Like Polypeptides as Thermosensitive Polymer System
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Local Delivery System Using Thermosensitive Hydrogel and Drug Loading Microspheres for Cartilage Repairing
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Graphene Oxide Reinforced Degradable Polyurethane for Anterior Cruciate Ligament Tissue Engineering
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Mixed Self-Assembled Monolayers Modified Electrode for the Detection of Human Neutrophil Elastase
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Evaluation of DNA Detection Kit for Authenticity of Unibract Fritillary Bulb Based on Pharmacopoeia Method
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Fabrication and Characterization of P34HB Scaffolds with Oriented Microtubules
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HomeAdvanced Materials ResearchAdvanced Materials Research Vol. 898Local Delivery System Using Thermosensitive...

Local Delivery System Using Thermosensitive Hydrogel and Drug Loading Microspheres for Cartilage Repairing

Abstract:

A local drug delivery system constituted by hybrid microsphere/thermosensitive hydrogel was fabricated for Osteoarthritis (OA) therapy in the research. The hydrogel were synthesized by ring-opening copolymerization. Microsphere was fabricated by O/W emulsion and solution evaporation method. The properties of the products were characterized by ¹HNMR, FTIR and phase transition diagram. The microsphere/hydrogel was prepared for in vitro drug release research. The results showed microsphere/hydrogel hybrid system can alleviate initial burst release. After 650 hours, only 60 percent of the drugs were released. Kinetics research implied the drug release is controlled by diffusion/erosion mechanism.