Preparation and Characterization of a Novel γ-PGA/β-Tricalcium Phosphate Composite for Tissue Engineering

Xiu Lin Shu; Qing Shan Shi; Xiao Bao Xie; Xiao Mo Huang; Yi Ben Chen

doi:10.4028/www.scientific.net/AMR.900.306

Paper Titles

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Synthesis and Properties of Esters of Amino Acids' Composite and Palmityl Alcohol
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Preparation and Characterization of a Novel γ-PGA/β-Tricalcium Phosphate Composite for Tissue Engineering
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HomeAdvanced Materials ResearchAdvanced Materials Research Vol. 900Preparation and Characterization of a Novel...

Preparation and Characterization of a Novel γ-PGA/β-Tricalcium Phosphate Composite for Tissue Engineering

Abstract:

In order to improvedβ-TCP biocompatibility and cell growth, was chosen to modify β-TCP matrices to produce a γ-PGA/β-TCP composite biomaterial. Then, the morphology, water uptake and retention abilities, in vitro degradation property in the simulated medium, cytotoxicity of this novel γ-PGA/β-TCP composite is investigated. SEM shows that the γ-PGA/β-TCP composite has a porous structure. By increasing the percentage ofγ-PGA from 0% to 50%, the swelling ratio of the composite s was enhanced from 9.0%to 297%. These data suggested that the surface hydrophilicity, water absorption rate, and swelling ratio were improved by adding γ-PGA to the composite. In the cytocompatibility test, the density of MC3T3-E1 preosteoblasts cells on the PTCP1:1 leachates was almost 110% higher than that on the controls on day 3. Therefore, the γ-PGA/β-TCP composite scaffolds, due to their better hydrophilicity, cytocompatibility, and porous structure, are very promising biomaterials for tissure engineering applications.

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Periodical:

Advanced Materials Research (Volume 900)

Pages:

306-311

DOI:

https://doi.org/10.4028/www.scientific.net/AMR.900.306

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Online since:

February 2014

Authors:

Xiu Lin Shu, Qing Shan Shi*, Xiao Bao Xie, Xiao Mo Huang, Yi Ben Chen

Keywords:

Biodegradation, Poly-γ-Glutamic Acid, Tissue Engineering, β-Tricalcium Phosphate

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