Hydrolytic Activity of a Neodymium(III) Complex in DNA Cleavage

Shu Lan Cai; Fa Mei Feng; Kang Quan Qiao; Ying Zhang; Xiu Lan Zhang

doi:10.4028/www.scientific.net/AMR.900.312

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Hydrolytic Activity of a Neodymium(III) Complex in DNA Cleavage
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HomeAdvanced Materials ResearchAdvanced Materials Research Vol. 900Hydrolytic Activity of a Neodymium(III) Complex in...

Hydrolytic Activity of a Neodymium(III) Complex in DNA Cleavage

Abstract:

A azamacrocyclic compound with carboxyl branch, 5,5,7,12,12,1-hexamethy-1,4 ,8,11-tetraazacyclo- tetradecane-N/-acetic acid(L), and its neodymium complex ware synthesized and characterized. The mode of combination of the neodymium complex with DNA was investigated by UV-vis absorption spectroscopy methods. The cutting function of the neodymium complex to supercoiled DNA was studied by gel electrophoresis method. The results show that metal complex can bind to the phosphate of DNA double helix and promote the hydrolysis of phosphodiester bond of supercoiled DNA(Form I); Supercoiled form DNA was transformed into nicked form DNA(Form II) with strong cutting effect of the macrocyclic neodymium complex; the reaction of DNA cut is completed by a hydrolysis mechanism.

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Periodical:

Advanced Materials Research (Volume 900)

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312-315

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https://doi.org/10.4028/www.scientific.net/AMR.900.312

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Online since:

February 2014

Authors:

Shu Lan Cai, Fa Mei Feng, Kang Quan Qiao, Ying Zhang, Xiu Lan Zhang

Keywords:

Enzyme Mimic, Hydrolytic Cleavage, Neodymium Complex, Phosphate Diester DNA

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