Antheraea pernyi Silk Fibroin Microspheres Carried Lysozyme

Abstract:

A method was developed to prepare the Antheraea Pernyi silk fibroin (ASF) microspheres using lysozyme as a model drug to estimate the application of ASF in drug controlled release field. The structure of ASF microsphere carried drug was characterized by X-ray diffraction and FTIR. The morphology and the influence of the microspheres on the degradation of lysozyme were investigated using scanning electron microscope. The results show that encapsulation rate was increased and drug content was decreased with the addition of lysozyme increasing. In vitro release of lysozyme from the ASF particles we demonstrated that the release kinetics depends on the pH. The pH played important roles in controlling lysozyme release profiles. It also can be seen that the degradation speed of lysozyme ASF microspheres slightly larger than the pure ASF microspheres.

• Periodical: Advanced Materials Research (Volumes 915-916)
• Pages: 875-878
• DOI: https://doi.org/10.4028/www.scientific.net/AMR.915-916.875
• Online since: April 2014
• Authors: Juan Wang, Gui Jun Li, Rui Jiang, Zhu Ping Yin, Shen Zhou Lu*
• Keywords: Antheraea Pernyi Silk Fibroin, Drug Delivery, Lysozyme, Microsphere

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