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Preparation and Characterization of Poly-γ-Glutamic Acid-Based Nanoparticles Biomacromolecules

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Abstract:

The present paper describes the preparation and characterization of novel biodegradable nanoparticles based on self-assembly of poly-γ-glutamic acid (γ-PGA). The nanosystems were stable inaqueous media at low pH conditions. Solubility of the systems was determined by turbidity measurements. Surface charge and mobility were measured electrophoretically. It was found that the size and size distribution of the nanosystems depends on the concentrations of γ-PGA solutions and their ratio as well as on the pH of the mixture and the order of addition. The average hydrodynamic diameters were between 150 and 330 nm. These biodegradable,self-assembling stable nanocomplexes might be useful for several biomedical applications.

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Periodical:

Advanced Materials Research (Volumes 915-916)

Pages:

891-894

DOI:

https://doi.org/10.4028/www.scientific.net/AMR.915-916.891

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Online since:

April 2014

Authors:

Ge Yang, Ke Shuai Lu, Xue Yan Su

Keywords:

Nanoparticle, Poly-γ-Glutamic Acid, Self-Assembly

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© 2014 Trans Tech Publications Ltd. All Rights Reserved

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