Preparation of PAA-Ch/Hydrogel, it Containing Bone Cell, PRP Nanocomposites and the Animal Trials

Te Hsing Wu; Hong Ru Lin

doi:10.4028/www.scientific.net/AMR.915-916.895

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HomeAdvanced Materials ResearchAdvanced Materials Research Vols. 915-916Preparation of PAA-Ch/Hydrogel, it Containing Bone...

Preparation of PAA-Ch/Hydrogel, it Containing Bone Cell, PRP Nanocomposites and the Animal Trials

Abstract:

In this paper, PAA-Ch/hydrogel compounds and it containing PRP (platelet-rich-plasma), bone cell composites were obtained by UV light or γ-ray irradiation method forscaffold material application. We utilized nanosized silica solution, natural chitosan and acrylicacid (AAc) as raw material to synthesize PAA-Ch/hydrogel products. The identified func-tional group peaks from FTIR has shown the evidence for the successful grafting of PAA-Ch-Si hydrogel nanocomposites through radiation co-polymerization procedure. The mechanical property analysis indicate that PAA-Ch/hydrogels have strong compressive strength and fitted friction coefficients when PAA incorporated with both chitosan and nano-silica. We also obtained that the animal models of PAA-Ch/ hydrogel composites and it incorporating PRP,bone cell as the bone supplying materials. The animal tests results proved that these composites are more compatible and efficacious for bone defect healing.

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Periodical:

Advanced Materials Research (Volumes 915-916)

Pages:

895-899

DOI:

https://doi.org/10.4028/www.scientific.net/AMR.915-916.895

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Online since:

April 2014

Authors:

Te Hsing Wu*, Hong Ru Lin

Keywords:

Bone Defect, Hydrogel Compounds, UV Light or γ-Ray Irradiation

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