XBP1S Induces GEP and Enhances Endochondral Bone Growth

Abstract:

We previously reported that transcription factor XBP1S is upregulated during chondrocyte differentiation and demonstrates the temporal and spatial expression pattern during skeletal development. Herein, we found that XBP1S stimulates chondrocyte differentiation from mesenchymal stem cells in vitro and endochondral ossification ex vivo. In addition, XBP1S activates granulin-epithelin precursor (GEP), a growth factor known to stimulate chondrogenesis, then enhances GEP-stimulated chondrogenesis and endochondral bone formation. Collectively, these findings demonstrate that XBP1S positively regulates endochondral bone formation by activating GEP chondrogenic growth factor.

• Periodical: Advanced Materials Research (Volumes 926-930)
• Pages: 1136-1139
• DOI: https://doi.org/10.4028/www.scientific.net/AMR.926-930.1136
• Online since: May 2014
• Authors: Feng Jin Guo*, Rong Jiang, Xiao Feng Han
• Keywords: BMP2, Chondrogenesis, PGRN, Unfolded Protein Response, X-Box Binding Protein 1 Spliced (XBP1S)

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