Hyaluronic Acid Functionalized Porous Silica Nanoparticles for Drug Delivery and Release

Abstract:

In this paper, we reported a facile strategy to synthesize hyaluronic acid (HA) conjugated porous silica nanoparticles (pSiO₂) as drug carrier. The pSiO₂ were prepared by solid nano-silica nanoparticles with “surface-protected etching”. Morphologies of solid and porous silica nanoparticles were characterized by SEM and TEM. Amino groups were introduced on pSiO₂ to graft HA as cancer targeting ligand. Then rifampicin used as model drug was loaded in pSiO₂-HA. The results indicate that pSiO₂ can perform a certain degree of slow release. Overall, the system might open the door to a new generation of carrier system for site-selective, controlled-release delivery of anticancer drugs.

• Periodical: Advanced Materials Research (Volume 936)
• Pages: 322-326
• DOI: https://doi.org/10.4028/www.scientific.net/AMR.936.322
• Online since: June 2014
• Authors: Ling Yuan Cui, Yan Hui Li*, Wei Zhang, Jing Peng Zhang, Qian Duan
• Keywords: Drug Delivery, Drug Release, Hyaluronic Acid, Porous Silica Nanoparticle

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