Synthesis of P1-Stavudine-P2-Zidovudine-5′,5′-Diphosphate

Cha Ma; Si Liu; Shan Shan Gong; Qi Sun

doi:10.4028/www.scientific.net/AMR.951.141

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HomeAdvanced Materials ResearchAdvanced Materials Research Vol. 951Synthesis of...

Synthesis of P¹-Stavudine-P²-Zidovudine-5′,5′-Diphosphate

Abstract:

P¹-Stavudine-P²-zidovudine-5′,5′-diphosphate has been synthesized efficiently from the phosphoropiperidate/4,5-dicyanoimidazole (DCI) system. The redox condensation protocol provided a chromatography-free method for the preparation of stavudine 5′-phosphoropiperidate from the corresponding stavudine 5′-phosphate.

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Periodical:

Advanced Materials Research (Volume 951)

Pages:

141-144

DOI:

https://doi.org/10.4028/www.scientific.net/AMR.951.141

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Online since:

May 2014

Authors:

Cha Ma, Si Liu, Shan Shan Gong, Qi Sun*

Keywords:

4,5-Dicyanoimidazole, Dinucleoside Diphosphate, Stavudine, Zidovudine

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* - Corresponding Author

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