Synthesis of β,γ-Bridging Oxygen-Modified Ribavirin 5′-Triphosphates

Qiang Wang; Shan Shan Gong; Qi Sun

doi:10.4028/www.scientific.net/AMR.951.145

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HomeAdvanced Materials ResearchAdvanced Materials Research Vol. 951Synthesis of β,γ-Bridging Oxygen-Modified...

Synthesis of β,γ-Bridging Oxygen-Modified Ribavirin 5′-Triphosphates

Abstract:

A novel P(V)–N activation strategy for the synthesis of β,γ-bridging oxygen-modified ribavirin 5′-triphosphates (β,γ-CX₂-NTPs, X = H, F, and Cl) from protected ribavirin 5′-phosphoropiperidates has been developed. The experimental results indicated that the employment of DCI activator could notably increase the product yield.

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Periodical:

Advanced Materials Research (Volume 951)

Pages:

145-148

DOI:

https://doi.org/10.4028/www.scientific.net/AMR.951.145

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Online since:

May 2014

Authors:

Qiang Wang, Shan Shan Gong, Qi Sun*

Keywords:

4,5-Dicyanoimidazole, Antiviral, Nucleoside Triphosphate, Phosphoropiperidate, Ribavirin

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