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Synthesis of Acyclovir β,γ-Methylene/Dihalomethylene Triphosphates

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Abstract:

Acyclovir β,γ-methylene/dihalomethylenetriphosphates were efficiently synthesized from acyclovir phosphoropiperidate obtained via the redox condensation with 2,2′-dipyridyldisulfide/PPh3 system. Promoted by 4,5-dicyanoimidazole (DCI), the phosphoropiperidate intermediate exhibited high reactivity toward the bisphosphonates.

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Periodical:

Advanced Materials Research (Volume 951)

Pages:

149-152

DOI:

https://doi.org/10.4028/www.scientific.net/AMR.951.149

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Online since:

May 2014

Authors:

Xiao Chuan Li, Shan Shan Gong, Qi Sun*

Keywords:

2,2′-Dithiodianiline, 4,5-Dicyanoimidazole, Acyclovir, Phosphonate, Triphosphate

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© 2014 Trans Tech Publications Ltd. All Rights Reserved

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* - Corresponding Author

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