The Characterization of Chitosan-Hyaluronan-Metal Nanocomposites

Abstract:

Chitosan and hyaluronan were used as biocompatible materials for biomedical application. In here, we prepared the Hyaluronan (HA) coated metal nanostructures. The chitosan (CS) films containing various concentrations of HA-coated Au or HA-coated Ag@Au nanostructures. We demonstrated that HA-coated spherical-like gold (HA-AuS), HA-coated wire-like gold (HA-AuW) or HA-coated Ag@Au could be dispersed in chitosan matrix by mixing and in aqueous solution casting. The introduction of HA-AuS, HA AuW and HA-Ag@Au nanostructures could not only improve the physical properties of CS, but also enhance the biocompatibility. The results revealed that the HA-AuS, HA AuW and HA-Ag@Au nanostructures enhanced the crystallinity of CS films. Besides, the hydrophilicity of CS films were improved by the HA-AuS, HA AuW and HA-Ag@Au nanostructures.

• Periodical: Advanced Materials Research (Volume 974)
• Pages: 97-101
• DOI: https://doi.org/10.4028/www.scientific.net/AMR.974.97
• Online since: June 2014
• Authors: Yang Chia Shih, Hui Hsuan Hsieh, Tzong Ming Wu, Chih Wei Chou*
• Keywords: Chitosan, Hyaluronan, Nanocomposite

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