Preliminary Metabonomic Analysis of Diabetic Rats Treated with Paired Extracts of Astragalus and Chinese Yams

Li Rong Wu; Zhong Feng Shi; Wei Dong Gao; Jia Yong Zhu

doi:10.4028/www.scientific.net/AMR.997.288

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HomeAdvanced Materials ResearchAdvanced Materials Research Vol. 997Preliminary Metabonomic Analysis of Diabetic Rats...

Preliminary Metabonomic Analysis of Diabetic Rats Treated with Paired Extracts of Astragalus and Chinese Yams

Abstract:

Combined extracts of Astragalus and the Chinese yam are an effective traditional Chinese medicine for treating diabetes. However, formal studies evaluating the effects of this combination of extracts have not been conducted. To examine the antidiabetic effects of this combination of extracts, we carried out a metabonomic study in rats. The collected liquid chromatography/mass spectrometry data were processed using the mixOmics R package. Clustered image maps (CIMs), networks, pattern recognition functions were used to perform preliminary metabonomic analysis, and the efficacy of the different treatments was evaluated. Our data demonstrated that these medicinal extracts may be useful in the treatment of diabetes through modulation of blood glucose levels and blood lipid indices. Additionally, the mixOmics package is a very useful and powerful tool for metabonomics study.

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Frontiers of Chemical Engineering, Metallurgical Engineering and Materials III

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Periodical:

Advanced Materials Research (Volume 997)

Pages:

288-291

DOI:

https://doi.org/10.4028/www.scientific.net/AMR.997.288

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Online since:

August 2014

Authors:

Li Rong Wu, Zhong Feng Shi, Wei Dong Gao, Jia Yong Zhu*

Keywords:

Astragalus, Chinese Yam, Diabetes, Metabonomics, Mixomics, R Function

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* - Corresponding Author

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