l-Stepholidine Blocks Methamphetamine-Induced Locomotor Sensitization in Mice

Bao Miao Ma; Kai Yue; Jun Qiao Xing; Xiao Kang Gong; Qin Ru; Lin Chen; Qi Xiong; Xiang Tian; Lu Liu; Yong Qing Gan; Dai Song Wang; Guo Zhang Jin; Chao Ying Li

doi:10.4028/www.scientific.net/AMR.998-999.156

Paper Titles

Research on Preparation and Properties of Textile Materials Deposited with Nanostructured Titanium Oxide
p.136

Ionization Cross Sections by Electron Impact for Single Ionization from the Atomic Ground State
p.140

Determination of Vitamin C Content in Brown Rice by Capillary Zone Electrophoresis
p.147

In Vitro and In Vivo Antitumor Efficacy of Curcumol Nanosuspension against H22 Tumor
p.151

l-Stepholidine Blocks Methamphetamine-Induced Locomotor Sensitization in Mice
p.156

20(S)-Ginsenoside Rg₃ Inhibits Human Glioma Cell Growth through the Suppression of Voltage-Gated K⁺ Channels
p.160

2Hz-Electroacupuncture Attenuates Conditioned Cue-Evoked Heroin-Seeking Behavior and Increase CB2-Rs Expression in Relapse-Relevant Brain Regions in Heroin-Addicted Rats
p.164

l-Stepholidine, a Naturally Occurring Dopamine D1 Receptor Agonist and D2 Receptor Antagonist, Attenuates Methamphetamine Self-Administration in Rats
p.169

Analysis of Factors and Characteristics in Patients with Hand-Foot-Mouth Disease
p.173

HomeAdvanced Materials ResearchAdvanced Materials Research Vols. 998-999l-Stepholidine Blocks Methamphetamine-Induced...

l-Stepholidine Blocks Methamphetamine-Induced Locomotor Sensitization in Mice

Abstract:

Repeating administration of methamphetamine (METH) can result in locomotor sensitization, a progressive increase in their psychomotor activating effects. l-Stepholidine (l-SPD), an alkaloid extract of the Chinese herb Stephania intermedia, is the first compound known to exhibit mixed dopamine D1 receptor agonist/D2 antagonist properties and is a potential medication for the treatment of drug addiction. Therefore, the effects of l-SPD on the hyperactivity, development and expression of METH-induced locomotor sensitization were investigated. The results indicated that l-SPD dose-dependently inhibited hyperlocomotion induced by acute METH and prevented the sensitized motor behavior induced by chronic METH administration. l-SPD likely acts as a D1 partial agonist and a D2 antagonist to produce its in vivo effects and may be a promising agent for treatment of METH addiction.

You might also be interested in these eBooks

Advances in Applied Sciences, Engineering and Technology II

View Preview

Info:

Periodical:

Advanced Materials Research (Volumes 998-999)

Pages:

156-159

DOI:

https://doi.org/10.4028/www.scientific.net/AMR.998-999.156

Citation:

Cite this paper

Online since:

July 2014

Authors:

Bao Miao Ma, Kai Yue, Jun Qiao Xing, Xiao Kang Gong, Qin Ru, Lin Chen, Qi Xiong, Xiang Tian, Lu Liu, Yong Qing Gan, Dai Song Wang, Guo Zhang Jin, Chao Ying Li*

Keywords:

Dopamine Receptor, Locomotor, L-Stepholidine, Methamphetamine, Sensitization

Export:

RIS, BibTeX

Price:

Permissions CCC:

Request Permissions

Permissions PLS:

Request Permissions

Сopyright:

Citation:

* - Corresponding Author

References

[1] Robinson TE, Becker JB. Enduring changes in brain and behavior produced by chronic amphetamine administration: a review and evaluation of animal models of amphetamine psychosis. Brain Res. 1986. 396(2): 157-98.

DOI: 10.1016/0165-0173(86)90002-0

Google Scholar

[2] Robinson TE, Berridge KC. The psychology and neurobiology of addiction: an incentive-sensitization view. Addiction. 2000. 95 Suppl 2: S91-117.

DOI: 10.1046/j.1360-0443.95.8s2.19.x

Google Scholar

[3] Creese I, Iversen SD. The pharmacological and anatomical substrates of the amphetamine response in the rat. Brain Res. 1975. 83(3): 419-36.

DOI: 10.1016/0006-8993(75)90834-3

Google Scholar

[4] Vezina P. Sensitization of midbrain dopamine neuron reactivity and the self-administration of psychomotor stimulant drugs. Neurosci Biobehav Rev. 2004. 27(8): 827-39.

DOI: 10.1016/j.neubiorev.2003.11.001

Google Scholar

[5] Paulson PE, Camp DM, Robinson TE. Time course of transient behavioral depression and persistent behavioral sensitization in relation to regional brain monoamine concentrations during amphetamine withdrawal in rats. Psychopharmacology (Berl). 1991. 103(4): 480-92.

DOI: 10.1007/bf02244248

Google Scholar

[6] Pierce RC, Kalivas PW. A circuitry model of the expression of behavioral sensitization to amphetamine-like psychostimulants. Brain Res Brain Res Rev. 1997. 25(2): 192-216.

DOI: 10.1016/s0165-0173(97)00021-0

Google Scholar

[7] Adinoff B. Neurobiologic processes in drug reward and addiction. Harv Rev Psychiatry. 2004. 12(6): 305-20.

DOI: 10.1080/10673220490910844

Google Scholar

[8] Jin GZ, Zhu ZT, Fu Y. (-)-Stepholidine: a potential novel antipsychotic drug with dual D1 receptor agonist and D2 receptor antagonist actions. Trends Pharmacol Sci. 2002. 23(1): 4-7.

DOI: 10.1016/s0165-6147(00)01929-5

Google Scholar

[9] Zou LL, Liu J, Jin GZ. Involvement of receptor reserve in D1 agonistic action of (-)-stepholidine in lesioned rats. Biochem Pharmacol. 1997. 54(2): 233-40.

DOI: 10.1016/s0006-2952(97)00153-6

Google Scholar