PLK1 Promotes Invasion of Esophageal Squamous Cell Carcinoma Cells through Inducing Epithelial-Mesenchymal Transition

Ji Yu Ju; Wen Jing Yu; Chun Ling Zhao

doi:10.4028/www.scientific.net/AMR.998-999.279

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HomeAdvanced Materials ResearchAdvanced Materials Research Vols. 998-999PLK1 Promotes Invasion of Esophageal Squamous Cell...

PLK1 Promotes Invasion of Esophageal Squamous Cell Carcinoma Cells through Inducing Epithelial-Mesenchymal Transition

Abstract:

PLK1 has been implicated in tumorigenesis and progression. The role of PLK1 in carcinogenesis has not been fully understood. In our study, we established PLK1-overexpressed stable transfectants in esophageal squamous cell carcinoma (ESCC) cells. Ectopic overexpression of PLK1 enhanced invasiveness of ESCC cells. Compared with the empty vector-transfected cells, PLK overexpression dramatically decreased expression of E-cadherin and increased expression of Vimentin in ESCC cells. Furthermore, Vimentin was also significantly increased at mRNA level in PLK overexpressed ESCC cells. These data suggest that PLK1 promotes invasion of ESCC cells by inducing EMT.

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Periodical:

Advanced Materials Research (Volumes 998-999)

Pages:

279-282

DOI:

https://doi.org/10.4028/www.scientific.net/AMR.998-999.279

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Online since:

July 2014

Authors:

Ji Yu Ju, Wen Jing Yu, Chun Ling Zhao*

Keywords:

EMT, Esophageal Squamous Cell Carcinoma, Invasion, Plk1

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* - Corresponding Author

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